not sure, I would say that safe mode is definitely giving an more easier option to bypass certain things;
- e.g. bypassing Gated Topics is a lot easier with safe mode then editing the CSS in devtools - for this specific component it actually requires quite some edits to get the “normal” experience.
- certain hidden elements could be revealed, that otherwise would never get reverse-engineered?
Obviously this is not something that I would be aware of, since I don’t expect an abuser to actually report his “bypass” method.