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Is it possible to use variables in the URLs? If yes, what’s the syntax for that?
I’d like to set the username as part of an URL.

I think it’s not possible. If by chance the link you want to customize leads to user preference, you can use /my/ such as: https://meta.discourse.org/my/preferences/interface.

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Thanks, but that’s not what I want. I actually want to link to another website which uses same usernames.

I think it may be achievable by using a custom, additional theme component to change the header’s link(s) dynamically, then.

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Yes, I thought about that, too, and searched through all theme components I could find, but no success. Do you know a component which could do that?