Sure, why not?
Just make sure, you‘ll have to expose the right port and set up this port for your domain in Cloudflare tunnels.
Personally, I don’t prefer this solution because it makes me dependent to Cloudflare and every tunnel agent puts a hole 
into my firewall, that makes me feel I‘m installing a trojan horse.
Firewall management is essential for server admins. You‘ll have some homework to do before exposing sites to the DMZ.