Can Docker Manager Update Caused NGINX Proxy Manager to Crash?

Because you are using reverse proxy.

And unsupported in this context means you won’t get any official support from the team, and because this category is, well, ment to be a support channel to supported things, you are kind of off topic too.

Un-supported/can’t get support doesn’t mean someone from the community and even from the team wouldn’t or couldn’t help you, though. We have here tons of un-supported and solved questions.