Some “issues” that come to mind: the buttons aren’t aligned, similar buttons aren’t next to each other (why are replace & append tags on separate lines, why are “[foo] topics” on 3 different lines, etc), only “relist topics” is smart, all other buttons appear at all times.
Suggested improvements:
Adjust the order of the buttons so similar buttons are better grouped.
Consider standardizing the button sizes so they are aligned.
Make all buttons “smart”. In the above screenshot, all selected topics are closed and unlisted - therefore “close topics” and “unlist topics” should not appear.
Provide tooltips to help new site staff: what exactly does “reset read” mean, what is the difference between replace tags and append tags, who does “change notification level” affect, etc.
Yes, I brought this up with @eviltrout today. At minimum this should have the appropriate glyphs (in grey, not black please – might want to make that a global CSS button style default) on the buttons.