Considering the Profile “landing” page is slated to become the Summary soon and this is somewhat edge case, probably not worth worrying about it much.
Typically, unless a Notifications link is specifically clicked I land on Profile Activity.
If I go to Profile (Activity) and click Notifications, there is a “Mark all as Read” button.
But if I go to User Card -> Avatar -> Profile (Activity) and click Notifications, the button is not there until I do a page reload.
             
            
              
              
              6 Likes
            
            
           
          
            
            
              On imgur they were saying it sometimes appears and sometimes does not – very likely a bug of some kind.
             
            
              
              
              2 Likes
            
            
           
          
            
              
                jomaxro
                (Joshua Rosenfeld)
              
              
                  
                  
              3
              
             
            
              I thought @sam removed the Mark all as read button a while back…I can’t find that button at all here on Meta.
             
            
              
              
              
            
            
           
          
            
              
                Falco
                (Falco)
              
              
                  
                  
              4
              
             
            
            
              
              
              
            
            
           
          
            
              
                jomaxro
                (Joshua Rosenfeld)
              
              
                  
                  
              7
              
             
            
              I could see it if I visited my notifications before visiting this topic.  If I go back now it is gone…
             
            
              
              
              
            
            
           
          
            
              
                gerhard
                (Gerhard Schlager)
              
              
                  
                  
              8
              
             
            
            
              
              
              5 Likes
            
            
           
          
            
              
                sam
                (Sam Saffron)
              
              
                  
                  
              9
              
             
            
              Vanishing buttons and disabled buttons seem to consistently cause confusion for no gain, we should probably change this
             
            
              
              
              10 Likes
            
            
           
          
            
            
              I support leaving it there for notifications since this has come up a few times already.
             
            
              
              
              4 Likes
            
            
           
          
            
              
                tgxworld
                (Alan Tan)
              
              
                  
                  
              11
              
             
            
            
              
              
              6 Likes