By default all 3 options are selected, but you can enter safe mode multiple times to isolate the culprit breaking your site.
I’m trying to make the point that now many people are on stable or, perhaps need reason to upgrade to the most recent version (I think that someone whom I just helped hadn’t upgraded anything since his install well over a year ago), can’t know when a #howto doesn’t apply to the version that they are running.
AFAIK, many if not most plugins have a form of “awesome_plugin_enabled” setting that can be used in control logic to some extent. I do not have as much understanding as I would like to have to know what the limitations are.
My understanding of “safe mode” (which is poor) is that it stops the plugin from being compiled as an asset. but that it does not stop it from being “readied”.
Maybe some kind of “file explorer” interface for the plugins directory would be a good approach?